Against Their Will is an extraordinary work, a plea for humanist ethics in science and medicine as against political and economic expediency. It takes us into even darker places than Hornblum’s earlier book as it examines the long history of unethical experiments done on children in America. Hornblum and his co-authors trace the hideous practice of using children, even infants and pregnant women, as guinea pigs, back to the ideology of the eugenicists in the early 20th century.